I'm in the same boat as David_C. Just switched to Windows 10. Have two INTERNAL HD's (not network drives) and want to have Windows app data, etc on drive C and Evernote database file on drive E. EN Options/Genera has a handy fill-in box to show where you want your local files to be. However, it won't let you type anything in. When you click on "Change" instead, full list of available drives is not shown... only user folders (such as app data!) It is very important to me that I be able to separate the Evernote files from system files. BTW, the EN program itself is on my E drive. I'm thinking this is a new Windows 10 issue. Anybody posted a support ticket on this?