I don't believe DebugView works under Wine, but I think I can accomplish the same thing by setting WINEDEBUG=+relay, and then grepping the results for "Debug" to capture all of the OutputDebugString calls, just like DebugView.
I've attached these results from using evernote for a minute or so, primarily clicking around and switching notebooks. I don't notice anything that particularly stands out -- my guess is it's some slowness in the ability of Wine to draw or update something.
Slow things: switching notebooks, the menus (file, edit, view), loading a PDF preview of some PDFs (might lock the program for 5 seconds or more when viewing such a note). The slow PDF preview for some PDFs I observed in Evernote 3.1 as well, however (count this as another vote to allow disabling automatic preview )
Some things are fast: searching for notes, switching notes within a notebook.
One thing that seems to have *stopped* working under Wine from Evernote 3.1 to 4.0 is pasting of some text. For example, I can copy and paste plain text, but I can't copy and paste text from my browser (presumably with HTML formatting). This worked before.
So it's good enough to use, just not great at the moment.
evernote.zip