I just wanted to throw my .02 in. I was experiencing this maddening issue too. I realized two things: I use Launchbar, which stores everything in my clipboard for the past day In Evernote, I employ the use of a single Notebook ("Cabinet"), and filter based off the tags in my system.This morning I cleared everything in my clipboard for LaunchBar, and set it to only keep the last 30 - 40 items. I also created a new notebook, and moved by note there to begin editing it. It is now 2:30 PM and I've been in Evernote all day without the slowness. Now, stupidly, I should have tried it after clearing the clipboard. Then, I'd know which item may have affected it, but again, this is only worth .02...sooo...hope this helps someone.