This is a very common issue for people with more than 2 keyboard layouts, it's just difficult to identify the problem. Please everybody, vote for this issue and get your friends to vote for it too, so it gets fixed soon.
Same problem here: after upgrading to Windows 10, when language switching hotkey is set to Ctrl+2, 3, 4, these combinations will freeze evernote. I had the same problem in Skype, and found a fix for it (running in compatibilty mode, see: http://community.skype.com/t5/Windows-desktop-client/hotkey-combination-hangs-Skype-on-Windows-10-TP/td-p/3862078/page/5). But it doesn't help for EN. This is incredibly annoying, please fix it.