I've gone through my own version of the process detailed in this thread once before after my Evernote Load/Unload time had increased to ~5 minutes. I exported my database, and then uninstalled Evernote along with making sure that Evernotes database files were also deleted. I then reinstalled Evernote and allowed it to repopulate the database. I thought that solved the problem as the Evernote Load/Unload was quick again. That was in early September 2014. At this point in time the Evernote Load/Unload times have again increased to ~4 minutes, and seem to be increasing more every day. I often have DebugView from SysInternals running and here are the Evenote logs that seem to be the point where it's getting stuck during the Load/Unload process. Unload: 00000001 12:20:00 PM  CBaseController::CloseBase: executed in 236.561947 sec 00000002 12:20:00 PM  CMainFrame::OnDestroy: executed in 236.562104 sec Load: 00000038 12:32:43 PM  # DeliverBaseOpenedNotifications: [inAppMessageController] executed in 225.022954 sec I'm using Evernote 22.214.171.12432 on Windows 7 Pro. It appears to me that repopulating the Database is only a temporary fix, and the real issue is still lurking about. This evernote database is also synced with another computer (one at work and one at home) The only computer that I've had issues with is the work computer. The other computer stills loads and unloads Evernote quickly. Update: I've just loaded the 5.7.2 update which has apparently fixed the issue. Evernote took ~10 minutes to response after updating, Once it came up though, shutdown and startup times were now quick when they were taking ~5 minutes for each.